Anaesthetic sensitivity in gamma-aminobutyric acid A β3 subunit mutant zebrafish
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چکیده
منابع مشابه
Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor.
1. The GABA modulating and GABA-mimetic actions of the general anaesthetic etomidate were examined in voltage-clamp recordings performed on Xenopus laevis oocytes induced, by cRNA injection, to express human recombinant gamma-aminobutyric acidA (GABAA) receptor subunits. 2. Currents mediated by recombinant receptors with the ternary subunit composition alpha x beta y gamma 2L (where x = 1,2,3 o...
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Levels of gamma-aminobutyric acid (GABA) in cerebrospinal fluid (CSF) were measured by radioreceptor assay (RRA) in 25 normal controls and in 121 patients with various central nervous system disorders. CSF-GABA levels could be measured down to 5 pmoles/ml reliably by this assay. In normal controls, the mean (+/- SEM) GABA level in CSF was 127 +/- 5.2 pmoles/ml. There was no correlation between ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2019
ISSN: 0007-0912
DOI: 10.1016/j.bja.2018.10.020